Blurred Publications

Complete List of Publications

Selected Publications


Kruspe SDickey DD, Urak KTBlanco GN Miller MJClark KCBurghardt E Gutierrez WRPhadke SDKamboj S Ginader TSmith BJGrimm SKSchappet JOzer HThomas A McNamara JOIIChan CH, Giangrande PHRapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology. Molecular Therapy Nucleic Acids. August 28, 2017. DOI: Epub 2017 Aug 12.
PMID: 28918054

Cover Article

Biomedicine Cover

Kruspe S, Giangrande PH. Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects Biomedicines. 2017 Aug 9;5(3). pii: E45. doi: 10.3390/biomedicines5030045. Review.
PMID: 28792479


Kruspe S, Giangrande PH. Design and Preparation of Aptamer-siRNA Chimeras (AsiCs) for Targeted Cancer Therapy. Methods Mol Biol. 2017;1632:175-186. doi: 10.1007/978-1-4939-7138-1_11.
PMID: 28730439


Toulmé JJ, Giangrande PH, Mayer G, Suess B, Ducongé F, Sullenger B, de Franciscis V, Darfeuille F, Peyrin E. Aptamers in Bordeaux, 24–25 June 2016Pharmaceuticals 2017, 10(1), 14; doi: 10.3390/ph10010014
PMID: 28117671


Thiel WH, Esposito CL, Dickey DD, Dassie JP, Long ME, Adam J, Streeter J, Schickling B, Takapoo M, Flenker KS, Klesney-Tait J, de Franciscis V, Miller FJ Jr, Giangrande PHSmooth Muscle Cell-Targeted RNA Aptamer Inhibits Neointimal FormationMol Ther. 2016 Jan 6. doi: 10.1038/mt.2015.235. 
PMID: 26732878


Dassie JP, Hernandez LI, Thomas GS, Long ME, Rockey WM, Howell CA, Chen Y, Hernandez FJ, Liu XY, Wilson ME, Allen LA, Vaena DA, Meyerholz DK, Giangrande PHTargeted Inhibition of Prostate Cancer Metastases with an RNA Aptamer to Prostate-specific Membrane Antigen. Mol Ther. 2014 Nov;22(11):1910-22. doi: 10.1038/mt.2014.117.
PMID: 24954476


Esposito CL, Cerchia L, Catuogno S, De Vita G, Dassie JP, Santamaria G, Swiderski P, Condorelli G, Giangrande PH, de Franciscis V. Multifunctional aptamer-miRNA conjugates for targeted cancer therapy. Mol Ther. 2014 Jun;22(6):1151-63. doi: 10.1038/mt.2014.5.
PMID: 24441398


Thiel KW, Hernandez LI, Dassie JP, Thiel WH, Liu X, Stockdale KR, Rothman AM, Hernandez FJ, McNamara JO 2nd, Giangrande PH. Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. Nucleic Acids Res. 2012 Jul;40(13):6319-37. doi: 10.1093/nar/gks294.
PMID: 22467215


Thiel WH, Bair T, Peek AS, Liu X, Dassie J, Stockdale KR, Behlke MA, Miller FJ Jr, Giangrande PH. Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. PLoS One. 2012; 7(9):e43836. doi: 10.1371/journal.pone.0043836.
PMID: 22962591


Rockey WM, Hernandez FJ, Huang SY, Cao S, Howell CA, Thomas GS, Liu XY, Lapteva N, Spencer DM, McNamara JO, Zou X, Chen SJ, Giangrande PH. Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. Nucleic Acid Ther. 2011 Oct;21(5):299-314. doi: 10.1089/nat.2011.0313.
PMID: 22004414


Pastor F, Kolonias D, Giangrande PH, Gilboa E. Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature. 2010 May 13;465(7295):227-30. doi: 10.1038/nature08999.
PMID: 20463739


Dassie JP, Liu XY, Thomas GS, Whitaker RM, Thiel KW, Stockdale KR, Meyerholz DK, McCaffrey AP, McNamara JO 2nd, Giangrande PHSystemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumorsNat Biotechnol. 2009 Sep;27(9):839-49. doi: 10.1038/nbt.1560.
PMID: 19701187


Giangrande PH, Zhang J, Tanner A, Eckhart AD, Rempel RE, Andrechek ER, Layzer JM, Keys JR, Hagen PO, Nevins JR, Koch WJ, Sullenger BA. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12988-93.
PMID: 17652516


McNamara JO 2nd, Andrechek ER, Wang Y, Viles KD, Rempel RE, Gilboa E, Sullenger BA, Giangrande PH. Cell type-specific delivery of siRNAs with aptamer-siRNA chimerasNat Biotechnol. 2006 Aug;24(8):1005-15.
PMID: 16823371


Giangrande PH, Zhu W, Schlisio S, Sun X, Mori S, Gaubatz S, Nevins JR. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcriptionGenes Dev. 2004 Dec 1;18(23):2941-51.
PMID: 15574595


Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR. Combinatorial gene control involving E2F and E Box family members. EMBO J. 2004 Mar 24;23(6):1336-47.
PMID: 15014447


Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR. Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol. 2003 Jun;23(11):3707-20.
PMID: 12748276